3-Methyl-GABA explained

3-Methyl-GABA, also known as HMS3266K11, is an anticonvulsant alkaloid.

Pharmacology

3-Methyl-GABA is an activator of GABA-T, an enzyme that transforms GABA to succinate semialdehyde and glutamate.^[1]

It also activates glutamate decarboxylase, an enzyme that is needed in GABA synthesis. This is thought to be the primary mechanism of action behind its anticonvulsant action.^{[2] [3]}

Notes and References

1. https://www.tocris.com/products/3-methyl-gaba_0386
2. https://www.medchemexpress.com/3-methyl-gaba.html
3. 3-Alkyl-4-aminobutyric acids: The first class of anticonvulsant agents that activates L-glutamic acid decarboxylase . 10.1021/jm00111a053 . 1991 . Silverman . Richard B. . Andruszkiewicz . Ryszard . Nanavati . Shrenik M. . Taylor . Charles P. . Vartanian . Mark G. . Journal of Medicinal Chemistry . 34 . 7 . 2295–2298 . 2067001 .