3-Methoxymorphinan Explained

3-Methoxymorphinan is an inactive metabolite of both dextromethorphan and levomethorphan, and has been shown to produce local anesthetic effects.^[1] It is the CYP3A4 metabolite of the aforementioned drugs,^[2] and is itself metabolized by the liver enzyme CYP2D6.^[3]

See also

• 3-hydroxymorphinan
• Dextrorphan
• Dextromethorphan
• Levomethorphan
• Morphinan

Notes and References

1. Hou CH, Tzeng JI, Chen YW, Lin CN, Lin MT, Tu CH, Wang JJ . Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats . European Journal of Pharmacology . 544 . 1–3 . 10–16 . August 2006 . 16844109 . 10.1016/j.ejphar.2006.06.013 .
2. Min DI, Ku YM, Vichiendilokkul A, Fleckenstein LL . A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers . Pharmacotherapy . 19 . 6 . 753–759 . June 1999 . 10391422 . 10.1592/phco.19.9.753.31536 . 32243163 .
3. Strauch K, Lutz U, Bittner N, Lutz WK . Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles . Food and Chemical Toxicology . 47 . 8 . 1928–1935 . August 2009 . 19445995 . 10.1016/j.fct.2009.05.004 .