3-Mercaptopropionic acid explained
3-Mercaptopropionic acid (3-MPA) is an organosulfur compound with the formula HSCH2CH2CO2H. It is a bifunctional molecule, containing both carboxylic acid and thiol groups. It is a colorless oil. It is derived from the addition of hydrogen sulfide to acrylic acid.
Reactions and uses
It is competitive inhibitor of glutamate decarboxylase, and therefore acts as a convulsant. It has higher potency and faster onset of action compared to allylglycine.[1]
It is used to prepare hydrophilic gold nanoparticles, exploiting the affinity of gold for sulfur ligands.[2]
It is esterified with polyols to form thiol-based polymer cross-linking agents such as pentaerythritol-based pentaerythritol tetrakis(3-mercaptopropionate).[3]
See also
Notes and References
- Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase. British Journal of Pharmacology. 49. 1. 52–63. 4207045. 1776427. 1973. Horton. R. W. Meldrum. B. S. 10.1111/j.1476-5381.1973.tb08267.x.
- Catalysis with TiO2/Gold Nanocomposites. Effect of Metal Particle Size on the Fermi Level Equilibration. Subramanian, Vaidyanathan . Wolf, Eduardo E. . Kamat, Prashant V.. Journal of the American Chemical Society. 2004. 126. 15 . 4943–4950. 10.1021/ja0315199. 15080700 .
- Hoyle . Charles E. . Bowman . Christopher N. . Thiol–Ene Click Chemistry . . 2010 . 49 . 9 . 10.1002/anie.200903924 . 1542–1543. 20166107 .
