3-MeO-PCMo explained

3-MeO-PCMo is a dissociative anesthetic drug which is similar in structure to phencyclidine^{[1] [2]} and been sold online as a designer drug.^{[3] [4]} The inhibitory effect of 3-MeO-PCMo on the reduction in the density of the drebrin clusters by NMDAR stimulation with glutamic acid is lower than that of PCP or 3-MeO-PCP, with half maximal inhibitory concentration (IC₅₀) values of 26.67 μM (3-MeO-PCMo), 2.02 μM (PCP) and 1.51 μM (3-MeO-PCP).^[5]

See also

• Arylcyclohexylamine
• Ketamine
• 3-HO-PCP
• 3-MeO-PCE
• 3-MeO-PCP
• 4-MeO-PCP
• Methoxyketamine

Notes and References

1. Ahmadi A, Khalili M, Hajikhani R, Naserbakht M . New morpholine analogues of phencyclidine: chemical synthesis and pain perception in rats . Pharmacology, Biochemistry, and Behavior . 98 . 2 . 227–33 . April 2011 . 21215770 . 10.1016/j.pbb.2010.12.019 . 24650035 .
2. Abiero A, Botanas CJ, Custodio RJ, Sayson LV, Kim M, Lee HJ, Kim HJ, Lee KW, Jeong Y, Seo JW, Ryu IS, Lee YS, Cheong JH . 6 . 4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels . Psychopharmacology . 237 . 3 . 757–772 . March 2020 . 31828394 . 10.1007/s00213-019-05412-y . 209169410 .
3. Colestock T, Wallach J, Mansi M, Filemban N, Morris H, Elliott SP, Westphal F, Brandt SD, Adejare A . 6 . Syntheses, analytical and pharmacological characterizations of the 'legal high' 4-[1-(3-methoxyphenyl)cyclohexyl]morpholine (3-MeO-PCMo) and analogues . Drug Testing and Analysis . 10 . 2 . 272–283 . February 2018 . 28513099 . 10.1002/dta.2213 .
4. Web site: 3-MeO-PCMo . New Synthetic Drugs Database . 2016-02-09 . https://web.archive.org/web/20160703113231/http://nsddb.eu/substance/510/ . 2016-07-03 . dead .
5. Mitsuoka T, Hanamura K, Koganezawa N, Kikura-Hanajiri R, Sekino Y, Shirao T . Assessment of NMDA receptor inhibition of phencyclidine analogues using a high-throughput drebrin immunocytochemical assay . Journal of Pharmacological and Toxicological Methods . 99 . 106583 . September–October 2019 . 31082488 . 10.1016/j.vascn.2019.106583 . free .