3-Maleylpyruvic acid explained

3-Maleylpyruvic acid, or 3-maleylpyruvate, is a dicarboxylic acid formed by the oxidative ring opening of gentisic acid by gentisate 1,2-dioxygenase during the metabolism of tyrosine.^[1] It is converted into 3-fumarylpyruvate by maleylpyruvate isomerase.^[2]

Notes and References

1. Sugiyama S, Yano K, Komagata K, Arima K . 1960 . Metabolites of aromatic compounds by microbes. Part VII. Gentisic acid oxidase . Bull. Agric. Chem. Soc. Jpn. . 24 . 243–248 .
2. Lack L . 1961 . Enzymic cis-trans isomerization of maleylpyruvic acid . J. Biol. Chem. . 236 . 11 . 2835–2840 . 10.1016/S0021-9258(19)76386-8 . 14461395. free .