3-Hydroxyvaleric acid explained

3-Hydroxyvaleric acid (3-hydroxypentanoic acid) is the organic compound with the formula . It is one of the hydroxypentanoic acids. It is made from odd carbon fatty acids in the liver and rapidly enters the brain. As opposed to 4-carbon ketone bodies, 3-hydroxyvaleric acid is anaplerotic, meaning it can refill the pool of TCA cycle intermediates. The triglyceride triheptanoin is used clinically to produce 3-hydroxyvalerate (the carboxylate form).^[1]

Properties

• Solubility in water: 784.8 g/L at 25 °C (estimated)^[2]

Notes and References

1. Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. Renée P. Kinman. Takhar Kasumov. Kathryn A. Jobbins. Katherine R. Thomas. Jillian Adams. Lisa N. Brunengraber. Gerd Kutz. Wolf-Ulrich Brewer. Charles R. Roe. Henri Brunengraber. amp. Am J Physiol Endocrinol Metab. E860–E866. 291. 10.1152/ajpendo.00366.2005. 2006. 16705058. 4 .
2. Web site: Human Metabolome Database: Showing metabocard for 3-Hydroxyvaleric acid (HMDB0000531) .