3-APPA explained

Cas Number:	103680-47-3
Unii:	QMT5SS3QRE
Pubchem:	121956
Iuphar Ligand:	1081
Chemspiderid:	10462431
Chembl:	112203
Iupac Name:	3-aminopropylphosphinic acid
C:	3
H:	10
N:	1
O:	2
P:	1
Smiles:	C(CN)CP(=O)O
Stdinchi:	1S/C3H10NO2P/c4-2-1-3-7(5)6/h7H,1-4H2,(H,5,6)
Stdinchikey:	ZTHNRNOOZGJLRR-UHFFFAOYSA-N

3-Aminopropylphosphinic acid, also known in the literature as 3-APPA or CGP 27492,^[1] is a compound used in scientific research which acts as an agonist at the GABA_B receptor. It is part of a class of phosphinic acid GABA_B agonists,^[2] which also includes SKF-97,541. It has a binding affinity (pK_i) to the GABA_B receptor of 8.30 (i.e., ~3 nM).^[3]

Notes and References

Web site: 3-APPA . IUPHAR/BPS Guide to Pharmacology . March 23, 2021.
Lacey G, Curtis DR . Phosphinic acid derivatives as baclofen agonists and antagonists in the mammalian spinal cord: an in vivo study . Experimental Brain Research . 101 . 1 . 59–72 . 1994 . 7843303 . 10.1007/BF00243217 . 19055950 .
Froestl W, Mickel SJ, von Sprecher G, Diel PJ, Hall RG, Maier L, Strub D, Melillo V, Baumann PA, Bernasconi R . 6 . Phosphinic acid analogues of GABA. 2. Selective, orally active GABA_B antagonists . Journal of Medicinal Chemistry . 38 . 17 . 3313–31 . August 1995 . 7650685 . 10.1021/jm00017a016 .