3-(imidazol-5-yl)lactate dehydrogenase explained

3-(imidazol-5-yl)lactate dehydrogenase
Ec Number:	1.1.1.111
Cas Number:	37250-42-3
Go Code:	0019155

In enzymology, a 3-(imidazol-5-yl)lactate dehydrogenase is an enzyme that catalyzes the chemical reaction

(S)-3-(imidazol-5-yl)lactate + NAD(P)+

\rightleftharpoons 3-(imidazol-5-yl)pyruvate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (S)-3-(imidazol-5-yl)lactate, NAD⁺, and NADP⁺, whereas its 4 products are 3-(imidazol-5-yl)pyruvate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-3-(imidazol-5-yl)lactate:NAD(P)⁺ oxidoreductase. This enzyme is also called imidazol-5-yl lactate dehydrogenase.

References

• Coote JG, Hassall H . The role of imidazol-5-yl-lactate-nicotinamide-adenine dinucleotide phosphate oxidoreductase and histidine-2-oxoglutarate aminotransferase in the degradation of imidazol-5-yl-lactate by Pseudomonas acidovorans . The Biochemical Journal . 111 . 2 . 237–9 . January 1969 . 4303364 . 1187811 .
• Cortese R, Brevet J, Hedegaard J, Roche J . [Identification and purification of an alpha-ketoacid aromatic reductase of Escherichia coli B] . French . Comptes Rendus des Séances de la Société de Biologie et de ses Filiales . 162 . 2 . 390–5 . 1968 . 4237631 .