3,4-Pr-PipVP explained

3,4-Pr-PipVP is a substituted cathinone derivative with stimulant effects which has been sold as a designer drug.^[1]

3,4-EtPV

3,4-Pr-PipVP was marketed online since 2021 as 3,4-EtPV, which is not covered by the controlled drug analogue laws in some jurisdictions such as Germany and Holland. However, while genuine 3,4-EtPV can be made and is now available from analytical suppliers as a reference standard, the benzocyclobutene ring system is relatively unstable and the synthesis is challenging, and all samples of supposed 3,4-EtPV that have been tested have proved to be 3,4-Pr-PipVP.^[2]

See also

• 4-Et-PVP
• 5-BPDi
• TCB-2
• TH-PVP
• Indapyrophenidone

Notes and References

1. Pulver B, Riedel J, Westphal F, Luhn S, Schönberger T, Schäper J, Auwärter V, Luf A, Pütz M . A new synthetic cathinone: 3,4-EtPV or 3,4-Pr-PipVP? An unsuccessful attempt to circumvent the German legislation on new psychoactive substances . Drug Testing and Analysis . 15 . 1 . 84–96 . January 2023 . 36136085 . 10.1002/dta.3371 . free .
2. Schwelm HM, Persson M, Pulver B, Huß MV, Gréen H, Auwärter V . Pharmacological profile, phase I metabolism, and excretion time profile of the new synthetic cathinone 3,4-Pr-PipVP . Drug Testing and Analysis . 16 . 3 . 277–288 . March 2024 . 37431186 . 10.1002/dta.3538 .