3(or 17)a-hydroxysteroid dehydrogenase explained

3(or 17)alpha-hydroxysteroid dehydrogenase
Ec Number:	1.1.1.209
Cas Number:	83294-77-3

3(or 17)alpha-hydroxysteroid dehydrogenase (3(17)alpha-hydroxysteroid dehydrogenase) is an enzyme with systematic name 3(or 17)alpha-hydroxysteroid:NAD(P)⁺ oxidoreductase.^{[1] [2]} This enzyme catalyses the chemical reaction

androsterone + NAD(P)+

\rightleftharpoons 5alpha-androstane-3,17-dione + NAD(P)H + H⁺

This enzyme acts on the 3alpha-hydroxy group of androgens of the 5alpha-androstane series; and also, more slowly, on the 17alpha-hydroxy group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase).

Notes and References

1. Lau PC, Layne DS, Williamson DG . A 3(17) alpha-hydroxysteroid dehydrogenase of female rabbit kidney cytosol. Purification and characterization of multiple forms of the enzyme . The Journal of Biological Chemistry . 257 . 16 . 9444–9 . August 1982 . 6955302 .
2. Lau PC, Layne DS, Williamson DG . Comparison of the multiple forms of the soluble 3(17) alpha-hydroxysteroid dehydrogenases of female rabbit kidney and liver . The Journal of Biological Chemistry . 257 . 16 . 9450–6 . August 1982 . 6955303 .