3β-Androstenol explained

3β-Androstenol, also known as 5α-androst-16-en-3β-ol, is a naturally occurring mammalian pheromone known to be present in humans and pigs.[1] [2] [3] It is thought to play a role in axillary odor. It is produced from androstenone via the enzyme 3β-hydroxysteroid dehydrogenase. Unlike its C3α epimer 3α-androstenol, 3β-androstenol shows no potentiation of the GABAA receptor or anticonvulsant activity.[4]

See also

Notes and References

  1. Kanlayavattanakul M, Lourith N . Body malodours and their topical treatment agents . International Journal of Cosmetic Science . 33 . 4 . 298–311 . 2011 . 21401651 . 10.1111/j.1468-2494.2011.00649.x . 11235250 . free .
  2. Book: Richard L. Doty. The Great Pheromone Myth. 27 January 2010. JHU Press. 978-0-8018-9347-6. 139–.
  3. Fischer J, Elsinghorst PW, Bücking M, Tholen E, Petersen B, Wüst M . Development of a candidate reference method for the simultaneous quantitation of the boar taint compounds androstenone, 3α-androstenol, 3β-androstenol, skatole, and indole in pig fat by means of stable isotope dilution analysis-headspace solid-phase microextraction-gas chromatography/mass spectrometry . Anal. Chem. . 83 . 17 . 6785–91 . 2011 . 21800819 . 10.1021/ac201465q .
  4. Sinclair PA, Hancock S, Gilmore WJ, Squires EJ . Metabolism of the 16-androstene steroids in primary cultured porcine hepatocytes . J. Steroid Biochem. Mol. Biol. . 96 . 1 . 79–87 . 2005 . 15896952 . 10.1016/j.jsbmb.2005.01.030 . 9435153 .

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