3β-Methoxypregnenolone explained

3β-Methoxypregnenolone (developmental code name MAP-4343), or pregnenolone 3β-methyl ether, also known as 3β-methoxypregn-5-en-20-one, is a synthetic neuroactive steroid and derivative of pregnenolone.[1] [2] [3] [4] It interacts with microtubule-associated protein 2 (MAP2) in a similar manner to pregnenolone and is under development for potential clinical use for indications such as the treatment of brain and spinal cord injury and depressive disorders.

See also

Notes and References

  1. Web site: Pregnenolone methyl ether - Mapreg - AdisInsight.
  2. Duchossoy Y, David S, Baulieu EE, Robel P . Treatment of experimental spinal cord injury with 3β-methoxy-pregnenolone . Brain Res. . 1403 . 57–66 . 2011 . 21704982 . 10.1016/j.brainres.2011.05.065 . 42657539 .
  3. Bianchi M, Baulieu EE . 3β-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders . Proc. Natl. Acad. Sci. U.S.A. . 109 . 5 . 1713–8 . 2012 . 22307636 . 3277154 . 10.1073/pnas.1121485109 . 2012PNAS..109.1713B . free .
  4. Baulieu ÉÉ . From steroid hormones to depressive states and senile dementias: New mechanistic, therapeutical and predictive approaches . Comptes Rendus Biologies . 338 . 8–9 . 613–6 . 2015 . 26251072 . 10.1016/j.crvi.2015.06.003 . free .

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