3α-Hydroxytibolone explained

3α-Hydroxytibolone (developmental code name ORG-4094) is a synthetic steroidal estrogen which was never marketed.[1] [2] Along with 3β-hydroxytibolone and δ4-tibolone, it is a major active metabolite of tibolone, and 3α-hydroxytibolone and 3β-hydroxytibolone are thought to be responsible for the estrogenic activity of tibolone.

Notes and References

  1. Kuhl. H. Pharmacology of estrogens and progestogens: influence of different routes of administration. Climacteric. 8. sup1. 2005. 3–63. 1369-7137. 10.1080/13697130500148875. 16112947. 24616324.
  2. Escande A, Servant N, Rabenoelina F, Auzou G, Kloosterboer H, Cavaillès V, Balaguer P, Maudelonde T . Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites . J. Steroid Biochem. Mol. Biol. . 116 . 1–2 . 8–14 . 2009 . 19464167 . 10.1016/j.jsbmb.2009.03.008 . 18346113 .

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