3,8-Dihydrodiligustilide Explained

3,8-Dihydrodiligustilide is a nonsteroidal phytoprogestogen that is found in Ligusticum chuanxiong.^{[1] [2]} It is a potent agonist of the progesterone receptor (EC₅₀ = 90 nM). Another compound in the plant, riligustilide, is also a phytoprogestogen, but is almost 1,000-fold less potent and is very weak in comparison (EC₅₀ ≈ 81 μM).

See also

• Kaempferol
• Tanaproget

Notes and References

1. Lim LS, Shen P, Gong YH, Yong EL . Dimeric progestins from rhizomes of Ligusticum chuanxiong . Phytochemistry . 67 . 7 . 728–34 . 2006 . 16516938 . 10.1016/j.phytochem.2006.01.024 . 2006PChem..67..728L .
2. Ahmed HM, Yeh JY, Lin WJ, Forsberg NE, Cheng WT, Ou BR . Validation of a luciferase bioassay to detect the progestative activity in gilts whose estrus was induced by an uterotonic herb (Ligusticum chuanxiong). Livestock Science. 163. 2014. 159–164. 1871-1413. 10.1016/j.livsci.2014.02.012.