Diiodotyrosine Explained

Diiodotyrosine should not be confused with diiodothyronine.

Diiodotyrosine (DIT) is a precursor in the production of thyroid hormone, and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring.

Function

DIT is a modulator of the enzyme thyroid peroxidase (which is involved in the production of thyroid hormones).^[1]

Triiodothyronine is formed, when diiodotyrosine is combined with monoiodotyrosine (in the colloid of the thyroid follicle).

Two molecules of DIT combine to make the thyroid hormone thyroxine ('T4' and 'T3').

See also

• Diiodotyrosine transaminase

Notes and References

1. Dème D, Fimiani E, Pommier J, Nunez J . Free diiodotyrosine effects on protein iodination and thyroid hormone synthesis catalyzed by thyroid peroxidase . Eur. J. Biochem. . 51 . 2 . 329–36 . February 1975 . 1149735 . 10.1111/j.1432-1033.1975.tb03932.x. free .