3,5,7-Trioxododecanoyl-CoA synthase explained

3,5,7-Trioxododecanoyl-CoA synthase
Ec Number:	2.3.1.206

3,5,7-Trioxododecanoyl-CoA synthase (TKS) is an enzyme with systematic name malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming).^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO₂

This polyketide synthase catalyse the first step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa.

Notes and References

1. Taura F, Tanaka S, Taguchi C, Fukamizu T, Tanaka H, Shoyama Y, Morimoto S . Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway . FEBS Letters . 583 . 12 . 2061–6 . June 2009 . 19454282 . 10.1016/j.febslet.2009.05.024 . 13746503 .
2. Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE . Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides . Proceedings of the National Academy of Sciences of the United States of America . 109 . 31 . 12811–6 . July 2012 . 22802619 . 3411943 . 10.1073/pnas.1200330109 . 2012PNAS..10912811G . free .