3,4-Dihydroxystyrene Explained

3,4-Dihydroxystyrene (DHS) is a centrally-acting inhibitor of the enzyme phenylalanine hydroxylase (PH).^[1] It is likely that DHS and other PH inhibitors will never have clinical applications on account of their capacity for inducing hyperphenylalaninemia and phenylketonuria.

See also

• Phenylalanine hydroxylase

Notes and References

1. Koizumi S, Matsushima Y, Nagatsu T, Iinuma H, Takeuchi T, Umezawa H . 3,4-dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases . Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology . 789 . 2 . 111–8 . September 1984 . 6148105 . 10.1016/0167-4838(84)90194-8 .