3,4-Dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+) explained

3,4-Dehydroadipyl-CoA semialdehyde dehydrogenase (NADP^+)
Ec Number:	1.2.1.77

3,4-Dehydroadipyl-CoA semialdehyde dehydrogenase (NADP⁺) (BoxD, 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase) is an enzyme with systematic name 3,4-didehydroadipyl-CoA semialdehyde:NADP+ oxidoreductase.^{[1] [2]} This enzyme catalyses the following chemical reaction

3,4-didehydroadipyl-CoA semialdehyde + NADP⁺ + H2O

\rightleftharpoons 3,4-didehydroadipyl-CoA + NADPH + H⁺

This enzyme catalyses a step in the aerobic benzoyl-coenzyme A catabolic pathway in Azoarcus evansii and Burkholderia xenovorans.

Notes and References

1. Gescher J, Ismail W, Olgeschläger E, Eisenreich W, Wörth J, Fuchs G . Aerobic benzoyl-coenzyme A (CoA) catabolic pathway in Azoarcus evansii: conversion of ring cleavage product by 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase . Journal of Bacteriology . 188 . 8 . 2919–27 . April 2006 . 16585753 . 1446997 . 10.1128/JB.188.8.2919-2927.2006 .
2. Bains J, Boulanger MJ . Structural and biochemical characterization of a novel aldehyde dehydrogenase encoded by the benzoate oxidation pathway in Burkholderia xenovorans LB400 . Journal of Molecular Biology . 379 . 3 . 597–608 . June 2008 . 18462753 . 10.1016/j.jmb.2008.04.031 .