3,4-Dimethylmethcathinone Explained

3,4-Dimethylmethcathinone (3,4-DMMC) is a stimulant drug first reported in 2010 as a designer drug analogue of mephedrone, apparently produced in response to the banning of mephedrone, following its widespread abuse in many countries in Europe and around the world.^[1] 3,4-DMMC has been seized as a designer drug in Australia.^[2] In vitro, 3,4-DMMC was shown to be a monoamine transporter substrate that potently inhibits norepinephrine and serotonin reuptake, and to a lesser extent dopamine reuptake.^[3]

Legal Status

As of October 2015 3,4-DMMC is a controlled substance in China.^[4]

3,4-DMMC is banned in the Czech Republic.^[5]

In the United States 3,4-DMMC is considered a Schedule I controlled substance as a positional isomer of 4-Methylethcathinone (4-MEC).^[6]

See also

• Serotonin–norepinephrine–dopamine reuptake inhibitor
• Serotonin–norepinephrine reuptake inhibitor
• Substituted cathinone
• Indanylaminopropane
• Methylone
• Xylopropamine

Notes and References

1. Web site: EMCDDA Annual Report 2010 . 2011-10-03 . 2012-03-14 . https://web.archive.org/web/20120314043454/http://www.emcdda.europa.eu/attachements.cfm/att_132857_EN_EMCDDA-Europol%20Annual%20Report%202010A.pdf . dead .
2. Locos O, Reynolds D . The characterization of 3,4-dimethylmethcathinone (3,4-DMMC) . Journal of Forensic Sciences . 57 . 5 . 1303–6 . September 2012 . 22564211 . 10.1111/j.1556-4029.2012.02142.x . 205770717 .
3. Luethi D, Kolaczynska KE, Docci L, Krähenbühl S, Hoener MC, Liechti ME . Pharmacological profile of mephedrone analogs and related new psychoactive substances . Neuropharmacology . 15 . 134 . 4–12 . 2018 . 28755886 . 10.1016/j.neuropharm.2017.07.026. 28786127 .
4. Web site: 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 . China Food and Drug Administration . 27 September 2015 . zh . 1 October 2015 . https://web.archive.org/web/20151001222554/http://www.sfda.gov.cn/WS01/CL0056/130753.html . 1 October 2015 . dead .
5. Web site: Látky, o které byl doplněn seznam č. 4 psychotropních látek (příloha č. 4 k nařízení vlády č. 463/2013 Sb.) . Ministerstvo zdravotnictví . cs . 2016-02-06 . 2016-03-09 . https://web.archive.org/web/20160309174659/http://www.mzcr.cz/Admin/_upload/files/3/Nov%C3%A9%20PL.pdf . dead .
6. Web site: Lists of: Scheduling Actions Controlled Substances Regulated Chemicals. U.S. Department of Justice. February 2023. 2023-03-05.