3,4-Difluoroamphetamine Explained

Drug Name:	3,4-Difluoroamphetamine
Iupac Name:	1-(3-Chlorophenyl)-N-methylpropan-2-amine
Width:	200px
Cas Number:	31338-32-6
Pubchem:	11182888
Chemspiderid:	9357973
C:	9
H:	11
F:	2
N:	1
Smiles:	CC(CC1=CC(=C(C=C1)F)F)N
Stdinchi:	1S/C9H11F2N/c1-6(12)4-7-2-3-8(10)9(11)5-7/h2-3,5-6H,4,12H2,1H3
Stdinchikey:	GJEXOPSQWJWJRQ-UHFFFAOYSA-N

3,4-Difluoroamphetamine (DFA) is a substituted amphetamine which has been sold as a designer drug. It has relatively weak activity as a serotonin releasing agent with only around 1/4 of the affinity for the serotonin transporter compared to MDA, but its activity at other targets has not been studied.^{[1] [2]}

See also

• 3-Fluoroamphetamine
• 3-Fluoromethamphetamine
• 4-Fluoroamphetamine
• 4-Fluoromethamphetamine
• 3,5-Difluoromethcathinone
• DFMDA
• DODC
• Xylopropamine

Notes and References

1. Roman DL, Saldaña SN, Nichols DE, Carroll FI, Barker EL . Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters . The Journal of Pharmacology and Experimental Therapeutics . 308 . 2 . 679–687 . February 2004 . 10.1124/jpet.103.057836 . 14593087 . 6439942 .
2. Walline CC, Nichols DE, Carroll FI, Barker EL . Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition . The Journal of Pharmacology and Experimental Therapeutics . 325 . 3 . 791–800 . June 2008 . 10.1124/jpet.108.136200 . 18354055 . 2637348 .