| Honorific-Prefix: | His Grace |
| The Duke of Devonshire | |
| Honorific-Suffix: | KG PC |
| Order: | Lord President of the Council |
| Term Start: | 6 July 1716 |
| Term End: | 16 March 1718 |
| Predecessor: | The Earl of Nottingham |
| Successor: | The Earl of Sunderland |
| Term Start2: | 27 March 1725 |
| Term End2: | 4 June 1729 |
| Monarch2: | George I George II |
| Predecessor2: | The Lord Carleton |
| Successor2: | The Lord Trevor |
| Nationality: | British |
| Party: | Whig |
| Spouse: | Rachel Russell |
| Children: | William Cavendish, 3rd Duke of Devonshire Lady Rachel Cavendish Lady Elizabeth Cavendish Lord James Cavendish Lord Charles Cavendish |
| Parents: | William Cavendish, 1st Duke of Devonshire Lady Mary Butler |
William Cavendish, 2nd Duke of Devonshire (1672 – 4 June 1729) was a British nobleman and politician. He was the eldest son of William Cavendish, 1st Duke of Devonshire and Lady Mary Butler. A prominent Whig, he was sworn of the Privy Council in 1707, and served as Lord President of the Council from 1716 to 1718 and 1725 to 1729.
He married The Hon. Rachel Russell (1674–1725), daughter of William Russell, Lord Russell on 21 June 1688. The Duchess served as a Lady of the Bedchamber at the court of Queen Anne.[1]
They had ten children: