CYB210010 explained

CYB210010 (2C-T-TFM) is a lesser-known psychedelic drug related to compounds such as 2C-T and 2C-T-21. Alexander Shulgin attempted to synthesise this compound in the 1990s, and mentions it in his book PiHKAL under the entry for 2C-T-21, but was unsuccessful in producing a key intermediate and never assigned it a 2C-T number. This compound was ultimately first synthesised by Geoffrey Varty and colleagues at Irish biopharmaceutical company Cybin in 2023. It has a K_i of 0.35 nM at 5-HT_2A, and an EC₅₀ of 4.1 nM at 5-HT_2A and 7.3 nM at 5-HT_2C, compared to 88 nM at 5-HT_2B.^[1] It is a potent, selective, long acting and orally active agonist for the 5-HT_2A and 5-HT_2C receptors and produces psychedelic-like responding in several different animal species.^[2] It is not known to have been tested in humans.

See also

• 2C (psychedelics)
• 2C-T-21.5
• 2C-T-28
• 2C-TFM
• 2C-TFE
• 3C-DFE
• DOPF
• Trifluoromescaline
• Tiflorex

Notes and References

1. WO . 2023156450 . Therapeutic phenethylamine compositions and methods of use . Nivorozhkin A, JA Hartsel, Canal CE, Salituro FG, Mueller TA, Greene BJ, Belser A, Avery KL, Reichelt AC, Varty GB, Palfreyman M . Cybin Irl Limited . 24 August 2023 .
2. Varty GB, Canal CE, Mueller TA, Hartsel JA, Tyagi R, Avery K, Morgan ME, Reichelt AC, Pathare P, Stang E, Palfreyman MG, Nivorozhkin A . Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT2 Receptor Agonist . Journal of Medicinal Chemistry . 67 . 8 . 6144–6188 . April 2024 . 38593423 . 10.1021/acs.jmedchem.3c01961 .