2C-T-21.5 Explained

2C-T-21.5 is a lesser-known psychedelic drug related to compounds such as 2C-T-21 and 2C-T-28. It was originally named by Alexander Shulgin and discussed in his book PiHKAL,^[1] but was not synthesised at that time. 2C-T-21.5 was ultimately synthesised and tested by Daniel Trachsel some years later. It has a binding affinity of 146 nM at 5-HT_2A and 55 nM at 5-HT_2C. It produes typical psychedelic effects, being slightly less potent but somewhat longer acting than 2C-T-2 or 2C-T-21,^{[2] [3] [4]} with an active dose of 12–30 mg, and a duration of action of 8–14 hours. Unlike 2C-T-21 it will not form the highly toxic fluoroacetate as a metabolite, instead producing the less toxic difluoroacetic acid.^{[5] [6]}

See also

• 2C-T-16
• 2C-T-TFM
• 2C-TFE
• 3C-DFE
• DOPF
• Trifluoromescaline
• 2C-x
• DOx
• 25-NB

Notes and References

1. Book: Alexander Shulgin . PiHKAL . 2C-T-21 .
2. Trachsel D . Fluorine in psychedelic phenethylamines . Drug Testing and Analysis . 2012 . 4 . 7–8 . 577–590 . 22374819 . 10.1002/dta.413 .
3. Luethi D, Trachsel D, Hoener MC, Liechti ME . Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs) . Neuropharmacology . 134 . Pt A . 141–148 . May 2018 . 28720478 . 10.1016/j.neuropharm.2017.07.012 .
4. Halberstadt AL, Luethi D, Hoener MC, Trachsel D, Brandt SD, Liechti ME . Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines . Psychopharmacology . 240 . 1 . 115–126 . January 2023 . 36477925 . 10.1007/s00213-022-06279-2 . 9816194 .
5. Book: Trachsel D, Lehmann D, Enzensperger C . 2013 . Phenethylamine: Von der Struktur zur Funktion . 789–791 . Nachtschatten Verlag AG . 978-3-03788-700-4.
6. Therapeutic phenethylamine compositions and methods of use. . Nivorozhkin A, Hartsel JA, Canal CE, Salituro FG, Mueller TA, Greene BJ, Belser A, Avery KL, Reichelt AC, Varty GB, Palfreyman M . WO . 2023/156450 . Cybin Irl Ltd. . 24 August 2023 .