27S pre-rRNA (guanosine2922-2'-O)-methyltransferase explained

27S pre-rRNA (guanosine^2922-2'-O)-methyltransferase
Ec Number:	2.1.1.167

27S pre-rRNA (guanosine²⁹²²-2'-O)-methyltransferase (Spb1p (gene), YCL054W (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:27S pre-rRNA (guanosine²⁹²²-2'-O-)-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons S-adenosyl-L-homocysteine + 2'-O-methylguanosine²⁹²² in 27S pre-rRNA

Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922.

Notes and References

1. Lapeyre B, Purushothaman SK . Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage . Molecular Cell . 16 . 4 . 663–9 . November 2004 . 15546625 . 10.1016/j.molcel.2004.10.022 . free .
2. Bonnerot C, Pintard L, Lutfalla G . Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast . Molecular Cell . 12 . 5 . 1309–15 . November 2003 . 14636587 . 10.1016/S1097-2765(03)00435-0 . free .