25TFM-NBOMe explained
25TFM-NBOMe (also known as NBOMe-2C-TFM, 2C-TFM-NBOMe, and Cimbi-138) is a derivative of the phenethylamine hallucinogen 2C-TFM, discovered in 2004 by Ralf Heim at the Free University of Berlin.[1] It acts as a potent partial agonist for the 5-HT2A receptor, though its relative potency is disputed, with some studies finding it to be of lower potency than 25I-NBOMe,[2] [3] while others show it to be of similar or higher potency,[4] possibly because of differences in the assay used.[5] 2C-TFM-NB2OMe can be taken to produce psychedelic effects similar to 2C-I-NB2OMe and 2C-D-NB2OMe.
Legality
United Kingdom
See also
Notes and References
- Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts . Heim R . PhD . Synthesis and pharmacology of potent 5-HT2A receptor agonists with N-2-methoxybenzyl substructure. Development of a new structure-activity relationship . 2004 . German .
- Theoretical study of the interaction of agonists with the 5-HT2A receptor. . Silva M . PhD . Universität Regensburg . 2009 .
- Silva ME, Heim R, Strasser A, Elz S, Dove S . Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor . Journal of Computer-Aided Molecular Design . 25 . 1 . 51–66 . January 2011 . 21088982 . 10.1007/s10822-010-9400-2 . 3103050 . 10.1.1.688.2670 . 2011JCAMD..25...51S .
- Ettrup A, Hansen M, Santini MA, Paine J, Gillings N, Palner M, Lehel S, Herth MM, Madsen J, Kristensen J, Begtrup M, Knudsen GM . 6 . Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT (2A) agonist PET tracers . European Journal of Nuclear Medicine and Molecular Imaging . 38 . 4 . 681–693 . April 2011 . 21174090 . 10.1007/s00259-010-1686-8 . 12467684 .
- Hansen M . Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain. . Ph.D. . University of Copenhagen . 2010-12-16 . 10.13140/RG.2.2.33671.14245.
