25N-NBPh explained

25N-NBPh (NBPh-2C-N) is a phenethylamine derivative from the 25-NB class, which acts as a potent agonist at the 5-HT_2A receptor with weaker activity at 5-HT_2B and 5-HT_2C. 25N-NBPh is a biased agonist, producing robust activation of 5-HT_2A coupled signalling pathways mediated by beta arrestin 2, but with only slight activation of pathways mediated via G_q. In animal studies it produces a modest head-twitch response when administered by itself, but blocks the effects of the fully active psychedelic DOI. ^{[1] [2] [3]}

See also

• 25N-NBOMe (NBOMe-2C-N)
• 25N-N1-Nap

Notes and References

1. WO . 2022241006 . Selective, Partial and Arrestin-Biased 5-HT2A Agonists with Utility in Various Disorders. . Wallach J, McCorvy J, Halberstadt A . Saint Joseph's University, The Medical College Of Wisconsin, Inc., The Regents Of The University Of California . 17 November 2022 .
2. Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD . 6 . Identification of 5-HT_2A Receptor Signaling Pathways Responsible for Psychedelic Potential . bioRxiv . July 2023 . 37577474 . 10418054 . 10.1101/2023.07.29.551106 .
3. Wallach, J., Cao, A.B., Calkins, M.M. et al. Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential. Nat Commun 2023; 14, 8221.