25N-N1-Nap Explained

25N-N1-Nap is a phenethylamine derivative from the 25-NB class, which acts as a potent agonist at the 5-HT_2A receptor with weaker activity at 5-HT_2B and 5-HT_2C. 25N-N1-Nap is a biased agonist, producing robust activation of 5-HT_2A coupled signalling pathways mediated by beta arrestin 2, but with little or no activation of pathways mediated via G_q. In animal studies it produces antipsychotic effects but without producing the head-twitch response associated with psychedelic activity.^{[1] [2]}

See also

• 25N-NBOMe (NBOMe-2C-N)
• 25N-NBPh
• 6-Fluoro-DET
• AAZ-A-154
• Lisuride
• (R)-69

Notes and References

1. WO . 2022241006 . Selective, Partial and Arrestin-Biased 5-HT2A Agonists with Utility in Various Disorders. . Wallach J, McCorvy J, Halberstadt A . Saint Joseph's University, The Medical College Of Wisconsin, Inc., The Regents Of The University Of California . 17 November 2022 .
2. Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD . 6 . Identification of 5-HT_2A Receptor Signaling Pathways Responsible for Psychedelic Potential . bioRxiv . July 2023 . 37577474 . 10418054 . 10.1101/2023.07.29.551106 .