25I-NB34MD explained

25I-NB34MD (NB34MD-2C-I) is a derivative of the phenethylamine hallucinogen 2C-I, which acts as a potent partial agonist for the human 5-HT_2A receptor, and presumably has similar properties to 2C-I.^[1] It has a binding affinity of 0.67nM at the human 5-HT_2A receptor, making it several times weaker than its positional isomer 25I-NBMD and a similar potency to 25I-NBF.^{[2] [3]}

Legality

Hungary

Illegal.^[4]

Japan

Illegal.^[5]

Sweden

The Riksdag added 25I-NB34MD to Narcotic Drugs Punishments Act under Swedish schedule I ("substances, plant materials and fungi which normally do not have medical use") as of June 9, 2015, published by Medical Products Agency (MPA) in regulation LVFS 2015:4 listed as 25I-NB34MD, and 2-(4-jodo-2,5-dimetoxifenyl)-N-[(3,4-metylendioxifenyl)metyl]etanamin.^[6]

United Kingdom

Notes and References

1. Uchiyama N, Kikura-Hanajiri R, Hakamatsuka T . 20296244 . A phenethylamine derivative 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(3,4-methylenedioxyphenyl)methyl]ethanamine (25I-NB34MD) and a piperazine derivative 1-(3,4-difluoromethylenedioxybenzyl)piperazine (DF-MDBP), newly detected in illicit products . Forensic Toxicology . January 2016 . 34 . 1 . 166–173 . 10.1007/s11419-015-0304-7.
2. Braden MR, Parrish JC, Naylor JC, Nichols DE . 15840304 . Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists . Molecular Pharmacology . 70 . 6 . 1956–64 . December 2006 . 17000863 . 10.1124/mol.106.028720 .
3. Towards a biophysical understanding of hallucinogen action . 1–176 . Ph.D. . Purdue University . 2007 . Michael Robert . Braden . vanc .
4. Web site: A Magyarországon megjelent, a Kábítószer és Kábítószer-függőség Európai Megfigyelő Központjának Korai Jelzőrendszerébe (EMCDDA EWS) 2005 óta bejelentett ellenőrzött anyagok büntetőjogi vonatkozású besorolása . Criminal classification of controlled substances published in Hungary and reported to the European Monitoring Center for Drugs and Drug Addiction (EMCDDA EWS) since 2005 . Hungarian . DAATH - A Magyar Pszichedelikus Közösség Honlapja (Homepage of the Hungarian Psychedelic Community) .
5. Web site: 指定薬物名称・構造式一覧（平成27年9月16日現在） . 厚生労働省 . 16 September 2015 . Japanese . 8 October 2015.
6. Web site: Föreskrifter om ändring i Läkemedelsverkets föreskrifter (LVFS 2011:10) om förteckningar över narkotika . Regulations on amendments to the Swedish Medicines Agency's regulations (LVFS 2011: 10) on the list of drugs . Swedish . Läkemedelsverket .