N-Benzyl-2C-B Explained

N-Benzyl-2C-B (25B-NB, NB-2C-B) is a recreational designer drug from the 25-NB subgroup of the substituted phenethylamine family, with psychedelic effects. It has a binding affinity (K_i) of 16 nM at the serotonin receptor 5-HT_2A and 90 nM at 5-HT_2C and reportedly has a potency in between that of 2C-B and NBOMe-2C-B.^{[1] [2]}

See also

• N-Ethyl-2C-B
• 25B-NBF
• 25B-NBOH

Notes and References

1. Glennon RA, Dukat M, el-Bermawy M, Law H, De los Angeles J, Teitler M, King A, Herrick-Davis K . Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines . Journal of Medicinal Chemistry . 37 . 13 . 1929–35 . June 1994 . 8027974 . 10.1021/jm00039a004 .
2. Book: Halberstadt AL . 2017 . Pharmacology and Toxicology of N-Benzylphenethylamine (“NBOMe”) Hallucinogens . Baumann M, Glennon R, Wiley J . Neuropharmacology of New Psychoactive Substances (NPS). . Current Topics in Behavioral Neurosciences . 32 . 283–311 . Springer . Cham . 10.1007/7854_2016_64 . 28097528 . 978-3-319-52444-3 .