| Unit Name: | 253 Squadron |
| Country: |  Israel |
| Size: | Squadron |
| Garrison: | Ramon Airbase |
| Nickname: | Negev Squadron |
| Aircraft Fighter: | Lockheed Martin F-16I Sufa |
thumb|300px|A Negev Squadron F-16I at Red Flag in 2009253 Squadron of the Israeli Air Force, also known as the Negev Squadron, is an F-16I fighter squadron based at Ramon Airbase.[1]
In March 2018, Israel's government confirmed that 253 Squadron, along with 69 and 119 Squadrons, took part and successfully completed Operation Orchard on 6 September 2007, destroying the nuclear installations of Syria constructed with the help of North Korea.[2]