23S rRNA pseudouridine2457 synthase explained

23S rRNA pseudouridine^2457 synthase
Ec Number:	5.4.99.20

23S rRNA pseudouridine²⁴⁵⁷ synthase (RluE, YmfC) is an enzyme with systematic name 23S rRNA-uridine²⁴⁵⁷ uracil mutase.^{[1] [2]} This enzyme catalyses the following chemical reaction

23S rRNA uridine²⁴⁵⁷

\rightleftharpoons 23S rRNA pseudouridine²⁴⁵⁷

The enzyme modifies uridine²⁴⁵⁷ in a stem of 23S RNA in Escherichia coli.

Notes and References

1. Del Campo M, Kaya Y, Ofengand J . Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli . RNA . 7 . 11 . 1603–15 . November 2001 . 11720289 . 1370202 .
2. Pan H, Ho JD, Stroud RM, Finer-Moore J . The crystal structure of E. coli rRNA pseudouridine synthase RluE . Journal of Molecular Biology . 367 . 5 . 1459–70 . April 2007 . 17320904 . 1876706 . 10.1016/j.jmb.2007.01.084 .