23S rRNA (uracil747-C5)-methyltransferase explained

23S rRNA (uracil^747-C^5)-methyltransferase
Ec Number:	2.1.1.189

23S rRNA (uracil⁷⁴⁷-C⁵)-methyltransferase (YbjF, RumB, RNA uridine methyltransferase B) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uracil⁷⁴⁷-C⁵)-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons S-adenosyl-L-homocysteine + 5-methyluracil⁷⁴⁷ in 23S rRNA

The enzyme specifically methylates uracil⁷⁴⁷ at C⁵ in 23S rRNA.

Notes and References

1. Madsen CT, Mengel-Jørgensen J, Kirpekar F, Douthwaite S . Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometry . Nucleic Acids Research . 31 . 16 . 4738–46 . August 2003 . 12907714 . 169892 . 10.1093/nar/gkg657 .