23S rRNA (pseudouridine1915-N3)-methyltransferase explained

23S rRNA (pseudouridine^1915-N^3)-methyltransferase
Ec Number:	2.1.1.177

23S rRNA (pseudouridine¹⁹¹⁵-N³)-methyltransferase (YbeA, RlmH, pseudouridine methyltransferase, m3Psi methyltransferase, Psi1915-specific methyltransferase, rRNA large subunit methyltransferase H) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (pseudouridine¹⁹¹⁵-N³)-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons S-adenosyl-L-homocysteine + N³-methylpseudouridine¹⁹¹⁵ in 23S rRNA

YbeA does not methylate uridine at position 1915.

Notes and References

1. Ero R, Peil L, Liiv A, Remme J . Identification of pseudouridine methyltransferase in Escherichia coli . RNA . 14 . 10 . 2223–33 . October 2008 . 18755836 . 2553739 . 10.1261/rna.1186608 .
2. Purta E, Kaminska KH, Kasprzak JM, Bujnicki JM, Douthwaite S . YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA . RNA . 14 . 10 . 2234–44 . October 2008 . 18755835 . 2553730 . 10.1261/rna.1198108 .