23S rRNA (guanosine2251-2'-O)-methyltransferase explained

23S rRNA (guanosine^2251-2'-O)-methyltransferase
Ec Number:	2.1.1.185

23S rRNA (guanosine²²⁵¹-2'-O)-methyltransferase (rlmB (gene), yifH (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanosine²²⁵¹-2'-O-)-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons S-adenosyl-L-homocysteine + 2'-O-methylguanosine²²⁵¹ in 23S rRNA

The enzyme catalyses the methylation of guanosine²²⁵¹.

Notes and References

1. Lövgren JM, Wikström PM . The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli . Journal of Bacteriology . 183 . 23 . 6957–60 . December 2001 . 11698387 . 95539 . 10.1128/jb.183.23.6957-6960.2001 .
2. Michel G, Sauvé V, Larocque R, Li Y, Matte A, Cygler M . The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot . Structure . 10 . 10 . 1303–15 . October 2002 . 12377117 . 10.1016/s0969-2126(02)00852-3 . free .