23S rRNA (guanine2069-N7)-methyltransferase explained

23S rRNA (guanine^2069-N^7)-methyltransferase
Ec Number:	2.1.1.264

23S rRNA (guanine²⁰⁶⁹-N⁷)-methyltransferase (rlmK (gene), 23S rRNA m7G2069 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine²⁰⁶⁹-N⁷)-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons S-adenosyl-L-homocysteine + N⁷-methylguanine²⁰⁶⁹ in 23S rRNA

The enzyme specifically methylates guanine²⁰⁶⁹ at position N⁷ in 23S rRNA.

Notes and References

1. Kimura S, Ikeuchi Y, Kitahara K, Sakaguchi Y, Suzuki T, Suzuki T . Base methylations in the double-stranded RNA by a fused methyltransferase bearing unwinding activity . Nucleic Acids Research . 40 . 9 . 4071–85 . May 2012 . 22210896 . 3351187 . 10.1093/nar/gkr1287 .