23S rRNA (cytosine1962-C5)-methyltransferase explained

23S rRNA (cytosine^1962-C^5)-methyltransferase
Ec Number:	2.1.1.191

23S rRNA (cytosine¹⁹⁶²-C⁵)-methyltransferase (RlmI, rRNA large subunit methyltransferase I, YccW) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (cytosine¹⁹⁶²-C⁵)-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons S-adenosyl-L-homocysteine + 5-methylcytosine¹⁹⁶² in 23S rRNA

The enzyme specifically methylates cytosine¹⁹⁶² at C⁵ in 23S rRNA.

Notes and References

1. Purta E, O'Connor M, Bujnicki JM, Douthwaite S . YccW is the m5C methyltransferase specific for 23S rRNA nucleotide 1962 . Journal of Molecular Biology . 383 . 3 . 641–51 . November 2008 . 18786544 . 10.1016/j.jmb.2008.08.061 .
2. Sunita S, Tkaczuk KL, Purta E, Kasprzak JM, Douthwaite S, Bujnicki JM, Sivaraman J . Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes . Journal of Molecular Biology . 383 . 3 . 652–66 . November 2008 . 18789337 . 10.1016/j.jmb.2008.08.062 .