23S rRNA (cytidine1920-2'-O)-methyltransferase explained

23S rRNA (cytidine^1920-2'-O)-methyltransferase
Ec Number:	2.1.1.226

23S rRNA (cytidine¹⁹²⁰-2'-O)-methyltransferase (TlyA) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (cytidine¹⁹²⁰-2'-O)-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytidine¹⁹²⁰ in 23S rRNA

\rightleftharpoons S-adenosyl-L-homocysteine + 2'-O-methylcytidine¹⁹²⁰ in 23S rRNA

This is a bifunctional enzyme from Mycobacterium tuberculosis.

Notes and References

1. Johansen SK, Maus CE, Plikaytis BB, Douthwaite S . Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs . Molecular Cell . 23 . 2 . 173–82 . July 2006 . 16857584 . 10.1016/j.molcel.2006.05.044 . free .
2. Maus CE, Plikaytis BB, Shinnick TM . Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis . Antimicrobial Agents and Chemotherapy . 49 . 2 . 571–7 . February 2005 . 15673735 . 547314 . 10.1128/AAC.49.2.571-577.2005 .