23S rRNA (adenine1618-N6)-methyltransferase explained

23S rRNA (adenine^1618-N^6)-methyltransferase
Ec Number:	2.1.1.181

23S rRNA (adenine¹⁶¹⁸-N⁶)-methyltransferase (rRNA large subunit methyltransferase F, YbiN protein, rlmF (gene), m6A1618 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine¹⁶¹⁸-N⁶)-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons S-adenosyl-L-homocysteine + N⁶-methyladenine¹⁶¹⁸ in 23S rRNA

The recombinant YbiN protein is able to methylate partially deproteinized 50 S ribosomal subunit.

Notes and References

1. Sergiev PV, Serebryakova MV, Bogdanov AA, Dontsova OA . The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel . Journal of Molecular Biology . 375 . 1 . 291–300 . January 2008 . 18021804 . 10.1016/j.jmb.2007.10.051 .