| Champ: | Alexander Zverev |
| Runner: | Nicolás Jarry |
| Score: | 6–4, 7–5 |
| Draw: | 96 (12 / 5) |
| Seeds: | 32 |
See main article: 2024 Italian Open (tennis).
Alexander Zverev defeated Nicolás Jarry in the final, 6–4, 7–5 to win the men's singles tennis title at the 2024 Italian Open. It was his sixth ATP Masters 1000 title and 22nd career title.[1]
Daniil Medvedev was the defending champion,[2] but lost to Tommy Paul in the fourth round.[3]
Hubert Hurkacz became the sixth player born in the 1990s (after Dominic Thiem, Stefanos Tsitsipas, Zverev, Grigor Dimitrov, and Medvedev) to reach at least the quarterfinals at all nine Masters events, and the eleventh active player overall to accomplish the feat.[4] Taylor Fritz became the first American man to reach the quarterfinals or better of all three clay court Masters events.[5]
Alejandro Tabilo and Jarry became the first Chilean players to reach a Masters semifinal since Fernando González at the 2009 Italian Open,[6] and marked the first time that multiple Chileans reached the semifinals of the same Masters event.[7] With his win against Novak Djokovic in the third round, Tabilo also became the second Chilean (after González) to defeat a reigning world No. 1.[8]
All seeds receive a bye into the second round.
The following are the seeded players. Seedings are based on ATP rankings as of 6 May 2024. Rankings and points before are as of 6 May 2024.
| Seed | Rank | Player | Points before | Points defending | Points earned | Points after | Status |
|---|---|---|---|---|---|---|---|
| 1 | 1 |  Novak Djokovic | 9,990 | 180 | 50 | 9,860 | Third round lost to Alejandro Tabilo [29] |
| 2 | 4 | Daniil Medvedev | 7,195 | 1,000 | 100 | 6,295 | Fourth round lost to  Tommy Paul [14] |
| 3 | 5 | Alexander Zverev | 5,435 | 90 | 1,000 | 6,345 | Champion, defeated Nicolás Jarry [21] |
| 4 | 6 | Andrey Rublev | 4,740 | 90 | 50 | 4,700 | Third round lost to  Alexandre Müller [Q] |
| 5 | 7 |  Casper Ruud | 4,535 | 360 | 10 | 4,185 | Second round lost to Miomir Kecmanović |
| 6 | 8 | Stefanos Tsitsipas | 3,860 | 360 | 200 | 3,700 | Quarterfinals lost to Nicolás Jarry [21] |
| 7 | 9 |  Hubert Hurkacz | 3,730 | (45)† | 200 | 3,885 | Quarterfinals lost to Tommy Paul [14] |
| 8 | 10 | Grigor Dimitrov | 3,605 | (90)† | 100 | 3,615 | Fourth round lost to Taylor Fritz [11] |
| 9 | 11 |  Alex de Minaur | 3,435 | (45)† | 100 | 3,490 | Fourth round lost to Stefanos Tsitsipas [6] |
| 10 | 12 | Holger Rune | 3,250 | 600 | 50 | 2,700 | Third round lost to  Sebastián Báez [17] |
| 11 | 13 | Taylor Fritz | 2,870 | (45)† | 200 | 3,025 | Quarterfinals lost to Alexander Zverev [3] |
| 12 | 14 | Ben Shelton | 2,460 | 10 | 50 | 2,500 | Third round lost to  Zhang Zhizhen |
| 13 | 15 | Ugo Humbert | 2,455 | (175)‡ | 0 | 2,280 | Withdrew due to knee injury |
| 14 | 16 | Tommy Paul | 2,300 | (45)† | 400 | 2,655 | Semifinals lost to Nicolás Jarry [21] |
| 15 | 17 |  Alexander Bublik | 2,055 | 45 | 10 | 2,020 | Second round lost to Nuno Borges |
| 16 | 18 | Karen Khachanov | 2,000 | 10 | 100 | 2,090 | Fourth round lost to Alejandro Tabilo [29] |
| 17 | 19 | Sebastián Báez | 1,960 | 25+60 | 100+10 | 1,985 | Fourth round lost to Hubert Hurkacz [7] |
| 18 | 20 |  Félix Auger-Aliassime | 1,880 | 10 | 50 | 1,920 | Third round lost to Alex de Minaur [9] |
| 19 | 21 | Adrian Mannarino | 1,875 | (20)† | 10 | 1,865 | Second round lost to Zhang Zhizhen |
| 20 | 22 | Francisco Cerúndolo | 1,870 | 180 | 50 | 1,740 | Third round lost to Karen Khachanov [16] |
| 21 | 24 | Nicolás Jarry | 1,675 | (30)† | 650 | 2,295 | Runner-up, lost to Alexander Zverev [3] |
| 22 | 25 | Frances Tiafoe | 1,650 | 45 | 10 | 1,615 | Second round lost to Dominik Koepfer |
| 23 | 26 | Tallon Griekspoor | 1,595 | 0 | 10 | 1,605 | |
| 24 | 27 | Sebastian Korda | 1,525 | 10 | 50 | 1,565 | Third round lost to Taylor Fritz [11] |
| 25 | 28 | Tomás Martín Etcheverry | 1,460 | 25+100 | 50+25 | 1,410 |