| Date: | 13–19 November |
| Edition: | 18th |
| Surface: | Clay |
| Venue: | Carrasco Lawn Tennis Club |
| Location: | Montevideo, Uruguay |
| Champs: |  Facundo Díaz Acosta |
| Champd: | Guido Andreozzi / Guillermo Durán |
The 2023 Uruguay Open was a professional tennis tournament played on red clay courts in Montevideo. It was the 18th edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place at the Carrasco Lawn Tennis Club in Montevideo, Uruguay between 13 and 19 November 2023.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Argentina | Pedro Cachin | 68 | 1 | |
| Argentina | Federico Coria | 88 | 2 | |
| Tomás Barrios Vera | 105 | 3 | ||
| Argentina | Facundo Díaz Acosta | 106 | 4 | |
| Alejandro Tabilo | 109 | 5 | ||
 Bolivia, Plurination;al State of | Hugo Dellien | 111 | 6 | |
| Argentina | Thiago Agustín Tirante | 119 | 7 | |
| Argentina | Francisco Comesaña | 122 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2023 Uruguay Open – Singles.
Facundo Díaz Acosta def. 
Thiago Monteiro 6–3, 4–3 ret.See main article: 2023 Uruguay Open – Doubles.
Guido Andreozzi / Guillermo Durán def. Boris Arias / Federico Zeballos 2–6, 7–6(7–2), [10–8].