| Champ: |  Dušan Lajović |
| Runner: | Andrey Rublev |
| Score: | 6–3, 4–6, 6–4 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Type: | singles doubles |
| Edition: | 1st |
See main article: article and 2023 Srpska Open.
Dušan Lajović defeated Andrey Rublev in the final, 6–3, 4–6, 6–4 to win the inaugural singles tennis title at the 2023 Srpska Open.[1]
The top four seeds received a bye into the second round.