The 2023 San Luis Open Challenger was a professional tennis tournament played on outdoor clay courts. It was the 28th edition of the tournament for the men which is part of the 2023 ATP Challenger Tour[1] and 1st edition for the women which is part of the 2023 WTA 125 tournaments.[2] It took place at the Club Deportivo Potosino in San Luis Potosí, Mexico between 27 March and 9 April 2023.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Australia | James Duckworth | 112 | 1 | |
| Antoine Bellier | 175 | 2 | ||
| Tomás Barrios Vera | 183 | 3 | ||
 Argentina | Renzo Olivo | 196 | 4 | |
| Argentina | Facundo Mena | 204 | 5 | |
 Japan | Rio Noguchi | 205 | 6 | |
| Argentina | Juan Pablo Ficovich | 209 | 7 | |
 Dominican Republic | Nick Hardt | 217 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Elisabetta Cocciaretto | 49 | 1 | |
| Tatjana Maria | 65 | 2 | ||
 Hungary | Dalma Gálfi | 79 | 3 | |
 Ukraine | Kateryna Baindl | 84 | 4 | |
| Kamilla Rakhimova | 92 | 5 | ||
 Austria | Julia Grabher | 94 | 6 | |
| Italy | Sara Errani | 99 | 7 | |
 Brazil | Laura Pigossi | 102 | 8 |
The following players received wildcards into the singles main draw:
Emiliana Arango Elisabetta Cocciaretto
María Fernanda Navarro Oliva Ana Sofía Sánchez Renata ZarazúaThe following players received entry from the qualifying draw:
Alizé Cornet → replaced by Elina Avanesyan
Jaqueline Cristian → replaced by 
Carol Zhao
Magdalena Fręch → replaced by 
Raluca Șerban
Katrina Scott
Aliona Bolsova
Tereza Martincová → replaced by Despina Papamichail
Rebecca Peterson → replaced by Kaja Juvan Lucrezia Stefanini → replaced by Fernanda Contreras Gómez Panna Udvardy → replaced by Paula Ormaechea Léolia Jeanjean (gastrointestinal illness)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 United Kingdom | Alicia Barnett | United Kingdom | Olivia Nicholls | 136 | 1 | |
 Georgia | Natela Dzalamidze | Kamilla Rakhimova | 153 | 2 | ||
| United States | Kaitlyn Christian | United States | Sabrina Santamaria | 168 | 3 | |
| Spain | Aliona Bolsova |  Venezuela, Bolivarian Republic of | Andrea Gámiz | 171 | 4 |
The following pair received a wildcard into the doubles main draw:
Nadia Podoroska (Papamichail - right knee injury) Elisabetta Cocciaretto / Julia Grabher (Grabher - left knee injury)See main article: 2023 San Luis Open Challenger – Men's singles.
See main article: 2023 San Luis Open Challenger – Women's singles.
Elisabetta Cocciaretto def. Sara Errani 5–7, 6–4, 7–5See main article: 2023 San Luis Open Challenger – Men's doubles.
Adam Walton def. Benjamin Lock / 
Rubin Statham 5–7, 6–3, [10–5].See main article: 2023 San Luis Open Challenger – Women's doubles.
Aliona Bolsova / Andrea Gámiz def. Oksana Kalashnikova / Katarzyna Piter 7–6(7–5), 6–4