| Date: | 12–18 June 2023 |
| Edition: | 15th |
| Surface: | Hard / Outdoor |
| Location: | Sumter, United States |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Yulia Starodubtseva |
| Champd: |  Maria Mateas / Anna Rogers |
The 2023 Palmetto Pro Open was a professional tennis tournament played on outdoor hard courts. It was the fifteenth edition of the tournament, which was part of the 2023 ITF Women's World Tennis Tour. It took place in Sumter, South Carolina, United States, between 12 and 18 June 2023.[1]
See main article: 2023 Palmetto Pro Open – Singles.
Yulia Starodubtseva def. 
Karman Thandi, 6–7(5–7), 7–5, 6–4See main article: 2023 Palmetto Pro Open – Doubles.
Maria Mateas / Anna Rogers def. McCartney Kessler / Yulia Starodubtseva, 6–4, 6–7(3–7), [10–6]| Country | Player | Rank | Seed | |
|---|---|---|---|---|
 Canada | Stacey Fung | 259 | 1 | |
| India | Karman Thandi | 268 | 2 | |
| United States | Liv Hovde | 297 | 3 | |
| United States | Ashley Lahey | 336 | 4 | |
| United States | Maria Mateas | 351 | 5 | |
| United States | Grace Min | 368 | 6 | |
| India | Rutuja Bhosale | 386 | 7 | |
| Ukraine | Yulia Starodubtseva | 391 | 8 |
The following players received wildcards into the singles main draw:
Usue Maitane Arconada Ashley Lahey Victoria Osuigwe Kennedy ShafferThe following players received entry from the qualifying draw:
Susana Alcaraz Piper Charney Haley Giavara Ava Markham
Martina Okáľová Layne Sleeth Mary Stoiana Akasha Urhobo