| Date: | 2–8 October |
| Edition: | 10th |
| Surface: | Hard (Indoor) |
| Location: | Mouilleron-le-Captif, France |
| Champs: |  Tomáš Macháč |
| Champd: |  Julian Cash /  Robert Galloway |
| Before Name: | Internationaux de Tennis de Vendée |
The 2023 Open de Vendée was a professional tennis tournament played on hard courts. It was the 10th edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Mouilleron-le-Captif, France between 2 and 8 October 2023.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | Hugo Gaston | 89 | 1 | |
| Dominic Stricker | 90 | 2 | ||
| France | Benjamin Bonzi | 98 | 3 | |
 Belgium | David Goffin | 102 | 4 | |
| Marc-Andrea Hüsler | 103 | 5 | ||
| United States | Maxime Cressy | 104 | 6 | |
| United Kingdom | Jack Draper | 106 | 7 | |
| Czech Republic | Tomáš Macháč | 118 | 8 |
The following players received wildcards into the singles main draw:
Pierre-Hugues Herbert Matteo Martineau Lucas PoullainThe following player received entry into the singles main draw as an alternate:
Valentin RoyerThe following players received entry from the qualifying draw:
Robin Bertrand Charles Broom Arthur Fery Adrien GobatSee main article: 2023 Open de Vendée – Singles.
Tomáš Macháč def. Arthur Fery 6–3, 6–4.See main article: 2023 Open de Vendée – Doubles.
Julian Cash / Robert Galloway def. Maxime Cressy / 
Otto Virtanen 6–4, 5–7, [12–10].