| Date: | 27 March – 2 April |
| Edition: | 2nd |
| Surface: | Clay |
| Location: | Mexico City, Mexico |
| Champs: | Dominik Koepfer |
| Champd: |  Boris Arias / Federico Zeballos |
| Main Name: | Mexico City Open (tennis) Mexico City Open |
The 2023 Mexico City Open was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Mexico City, Mexico between 27 March and 2 April 2023.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Marc-Andrea Hüsler | 47 | 1 | ||
 Colombia | Daniel Elahi Galán | 89 | 2 | |
 Argentina | Facundo Bagnis | 100 | 3 | |
 Australia | James Duckworth | 112 | 4 | |
| Yannick Hanfmann | 134 | 5 | ||
| Alejandro Tabilo | 162 | 6 | ||
 Brazil | Felipe Meligeni Alves | 164 | 7 | |
 Italy | Luciano Darderi | 173 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Térence Atmane Federico Gaio Juan Ignacio Londero
Maximilian NeuchristSee main article: 2023 Mexico City Open – Singles.
Thiago Agustín Tirante 2–6, 6–4, 6–2.See main article: 2023 Mexico City Open – Doubles.
Boris Arias / Federico Zeballos def. 
Evan King / Reese Stalder 7–5, 5–7, [10–2].