See main article: 2023 Libéma Open.
Defending champion Ekaterina Alexandrova[1] defeated Veronika Kudermetova in the final, 4–6, 6–4, 7–6(7–3) to win the women's singles tennis title at the 2023 Libéma Open. Alexandrova lost just one set en route to the title, to Kudermetova in the final, ending a winning streak of 18 consecutive sets at the tournament. Alexandrova became the first player to defend the title at 's-Hertogenbosch since Tamarine Tanasugarn in 2009, and just the second player to defend the title overall. Furthermore, she became the first player to defend a WTA Tour grass court title since Petra Kvitová at the 2018 Birmingham Classic.