See main article: 2023 Knoxville Challenger.
Hunter Reese and Tennys Sandgren were the defending champions[1] but only Sandgren chose to defend his title, partnering Marcus Willis. Sandgren lost in the quarterfinals to Evgeny Karlovskiy and Nino Serdarušić.
Cannon Kingsley and Luis David Martínez won the title after defeating Mac Kiger and Mitchell Krueger 7–6(7–3), 6–3 in the final.