| Date: | 4–10 September |
| Edition: | 37th |
| Surface: | Hard |
| Location: | Istanbul, Turkey |
| Champs: |  Damir Džumhur |
| Champd: |  Luke Johnson /  Skander Mansouri |
The 2023 Istanbul Challenger was a professional tennis tournament played on hard courts. It was the 37th edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Istanbul, Turkey between 4 and 10 September 2023.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Korea, Republic of | Kwon Soon-woo | 104 | 1 | |
| Jesper de Jong | 141 | 2 | ||
 Slovakia | Lukáš Klein | 155 | 3 | |
| Dino Prižmić | 176 | 4 | ||
 Belgium | Gauthier Onclin | 198 | 5 | |
 France | Harold Mayot | 204 | 6 | |
| Bosnia and Herzegovina | Damir Džumhur | 211 | 7 | |
| Slovakia | Norbert Gombos | 217 | 8 |
The following players received wildcards into the singles main draw:
Tuncay Duran Koray Kırcı Ergi KırkınThe following players received entry from the qualifying draw:
See main article: 2023 Istanbul Challenger – Singles.
Damir Džumhur def. Lukáš Klein 7–6(7–5), 6–3.See main article: 2023 Istanbul Challenger – Doubles.
Luke Johnson / Skander Mansouri def. Sander Arends / 
Aisam-ul-Haq Qureshi 7–6(7–3), 6–3.
