| Date: | September 18–24 |
| Edition: | 13th |
| Draw: | 32S / 16D |
| Surface: | Hard (indoor) |
| Location: | Columbus, United States |
| Venue: | Ohio State Varsity Tennis Center |
| Champs: |  Denis Kudla |
| Champd: | Robert Cash /  James Trotter |
| Before Name: | Columbus Challenger II |
The 2023 Columbus Challenger was a professional tennis tournament played on indoor hard courts. It was the 13th edition of the men's tournament which was part of the 2023 ATP Challenger Tour. It took place in Columbus, United States between September 18 and 24, 2023.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | Enzo Couacaud | 178 | 1 | |
| United States | Denis Kudla | 181 | 2 | |
 Ecuador | Emilio Gómez | 185 | 3 | |
 Canada | Vasek Pospisil | 187 | 4 | |
| United States | Tennys Sandgren | 196 | 5 | |
| Canada | Alexis Galarneau | 200 | 6 | |
 Australia | Adam Walton | 203 | 7 | |
| United States | Zachary Svajda | 207 | 8 |
The following players received entry into the singles main draw as wildcards:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
See main article: 2023 Columbus Challenger – Singles.
Denis Kudla def. Alexis Galarneau 6–2, 6–1.See main article: 2023 Columbus Challenger – Doubles.
Robert Cash / James Trotter def. 
Guido Andreozzi / 
Hans Hach Verdugo 6–4, 2–6, [10–7].
