See main article: 2023 Chile Open.
Nicolás Jarry defeated Tomás Martín Etcheverry in the final, 6–7(5–7), 7–6(7–5), 6–2 to win the singles tennis title at the 2023 Chile Open. This was Jarry's first ATP title since 2019.
Pedro Martínez was the defending champion, but lost in the first round to Yannick Hanfmann.[1]
The top four seeds received a bye into the second round.